Hereditary Cancer Testing

Germline NGS Analysis for Inherited Cancer Risk

OVERVIEW

Understanding hereditary cancer risk can be illuminating both for patients and their families: Results can help establish or confirm a diagnosis, guide personalized medical management, and identify risk for other cancers or conditions - while also informing close biological relatives of their own potential risk factors.

At Fulgent Oncology, our carefully-designed hereditary cancer panels are tailored to include the most relevant genes for your patient. And for those cases that don't fit into typical classifications, comprehensive and flexible options are also available.

Panel Coverage: ≥99% at 50x
Deletion / Duplication: As low as 1 exon resolution
Sequencing Methods: NGS
Orthogonal Methods: Sanger, qPCR, MLPA
Turnaround Time: 2-3 weeks

SPECIMEN REQUIREMENTS

Blood (two 4ml EDTA tubes, lavender top), Extracted DNA (3ug in EB buffer)

Patients Who Have Undergone Blood Transfusions

Recent packed cell/platelet transfusion or whole blood transfusion patients should wait at least 2-4 weeks prior blood draw for testing. If DNA quality is insufficient, additional samples will be requested.

Patients who have undergone a Bone Marrow Transplant or have a hematologic malignancy

DNA extracted from cultured fibroblasts should be submitted instead of blood/saliva/buccal samples from individuals who have undergone allogeneic bone marrow transplant and from patients with hematologic malignancy.

Who is Germline Hereditary Cancer testing for?

Adults with a personal or family history suggestive of a hereditary cancer syndrome. Red flags for a hereditary cancer susceptibility could include onset of cancer prior to the age of 50 years, more than one primary cancer in a single person, and multiple affected people within a family.

An adult with a blood relative with a known germline pathogenic/likely pathogenic variant in a cancer susceptibility gene. This test is designed to detect individuals with a germline pathogenic variant, and is not validated to detect mosaicism below the level of 20%. It should not be ordered on tumor tissue.

If interested in somatic testing please see options below to learn more

Select a pre-curated panel or customize panels at no additional charge

Comprehensive results are displayed in a concise report

As low as 1 exon resolution

Our Panels

Hereditary cancer panels can be customized. For additional information please check out Custom Comprehensive Cancer Panel page.

Focus

Focus Cancer Panels covers genes associated with high/moderate risk for hereditary cancer syndromes and established clinical management guidelines for disease-causing variant (pathogenic variant). These panels provide the most optimal balance between detection of actionable pathogenic cancer susceptibility pathogenic variants, and minimizing the number of variants of unknown clinical significance reported.

Panels

Comprehensive

Comprehensive Cancer Panels covers genes associated with potential risk for hereditary cancer syndromes. These panels include well-established cancer-related genes (this includes all Focus panel genes) as well as candidate genes with newly discovered association with cancer, but may have reduced or unclear risk. Patients and families with complex presentations may benefit from more comprehensive testing. Comprehensive Cancer Panels maximize the chance of identifying disease-causing variants and provide an extensive review of potential cancer risks from additional candidate genes.

Panels

*TAT: 10 Days

Highlights of Coverage and Analysis

Typical coverage for coding sequences: ≥99% at ≥ 50x
BRCA2: Portuguese Founder Mutation
MSH2: Boland Inversion (exon 1-7 inversion)
PTEN: Promoter region
TP53: Promoter region
CDKN2A: p14ARF and p16 protein products
PMS2: Analysis includes exons 1-5 and 12-15
TERT: Promoter region
GREM1: Promoter region

FOR HEREDITARY CANCER TESTING

How It Works

Collect the sample

Sample collection kits are available upon request.

Place your order

Order on the portal or download and fill out our paper requisition.

Ship the sample to Fulgent

Send specimen and completed requisition to Fulgent Oncology.

Receive your report

All reports will be available for download in your portal within 2-3 weeks.

Customize for your Patient

Customize patient care by adding or removing any of our 154 cancer genes to suit your patient's condition and clinical management. Take advantage of our no additional charge re-requisition process to expand the diagnostic quest to any other gene in the cancer tests within 3 months.

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